Aplicação da nanotecnologia no combate à doenças orais biofilme dependentes: Revisão de literatura

Juliana Campos Pinheiro, Gabriel Gomes da Silva, Daniel Matias de Araujo, Matheus silva de Oliveira Costa, Daniel Felipe Fernandes Paiva, Karla Beatriz de Freitas Lira

Resumo


Diversas doenças infecciosas bucais, como a cárie e periodontite, são provocadas devido a formação de biofilme supra e/ou subgengival. A partir daí, a nanotecnologia surge com novas abordagens no tratamento contra as doenças biofilme dependentes, visando a inibição e destruição do biofilme. Nesta revisão de literatura, coletamos os estudos mais atuais que abordam essa perspectiva, a partir da busca nos bancos de dados Pubmed e Portal Regional da BVS, selecionando artigos publicados entre os anos de 2012 e 2019. Foi observado diversas técnicas promissoras nesse contexto, como o uso de nanopartículas metálicas (como ouro, prata e óxido de ferro), nanocompósitos, nanobolhas induzidas por laser e confecção de adesivos e materiais restauradores com nanoparticulas bactericidas/bacteriostáticas. Com isso, a nanotecnologia promete grandes avanços nos tratamentos odontológicos, porém, ainda sendo necessário estudos in vivo, para a consolidação dos resultados.


Palavras-chave


Nanotecnologia; biofilme bacteriano; microbiota.

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Refer?ncias


Besinis A, Peralta T, Handy RD. The antibacterial effects of silver, titanium dioxide and silica dioxide nanoparticles compared to the dental disinfectant chlorhexidine on Streptococcus mutans using a suite of bioassays. Nanotoxicology, 8:1, 1-16, 2012.

Feng QL, Wu J, Chen GQ, Cui FZ, Kim TN, Kim JO. A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. J Biomed Mater Res, 52:662668, 2000.

Foldjerg R, Olesen P, Hougaard M, Dang DA, Hoffmann HJ, Autrup H. PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes. Toxicol Lett, 190:156162, 2009.

Weber DJ, Rutala WA. Use of metals as microbicides in preventing infections in healthcare. In: Block SS, editor. Disinfection, sterilization, and preservation. Philadelphia: Lippincott Williams and Wilkins, 2001, pp 415-427.

Jie Li, Ranchel Nickel, Jiandong Wu, Francis Lin, Johan Lierop, Song Liu. A new tool to attack biofilms: driving magnetic iron-oxide nanoparticles to disrupt the matrix. The Royal Society of Chemistry, 2019.

Pham DTN et al. Biofilm inhibition, modulation of virulence and motility properties by FeOOH nanoparticle in Pseudomonas aeruginosa. Sociedade Brasileira de Microbiologia, 2019.

Lapotko D. Plasmonic nanoparticle-generated photothermal bubbles and their biomedical applications. Nanomedicine, Vol. 4, N. 7, 2009.

Xiong R et al. Cytosolic Delivery of Nanolabels Prevents Their Asymmetric Inheritance and Enables Extended Quantitative in Vivo Cell Imaging. Nano Letters, 2016.

Teirlinck El et al. Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms. Nature Comunications. 2018.

Terlinck E et al. Exploring Light-Sensitive Nanocarriers for Simultaneous Triggered Antibiotic Release and Disruption of Biofilms Upon Generation of Laser-Induced Vapor Nanobubbles. Pharmaceutics. Vol. 11 Ed. 5, 2019.

Torres CRG, Kubo CH, Anido A, Rodrigues JR. Agentes antimicrobianos e seu potencial de uso na Odontologia. Rev Fac Odontol São José dos Campos, v.3, n.2, jul./dez., 2000.

Samaranayake. Fundamentos de Microbiologia e Imunologia na Odontologia, 2012.

Gao L et al. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nature Nanotechnol. 2 (9) (2007) 786e796.

Noyori R, Aoki M, Sato K. Green oxidation with hydrogen peroxide. Chem. Commun.

Marsall MV, Cancro LP, Fischman SL. Hydrogen Peroxide: a review of its use in dentistry. J. Periodontol. 66 (9) (1995) 786e796.

Gao L et al. Nanocatalysts promote Streptococcus mutans biofilm matrix degradation and enhance bacterial killing to suppress dental caries in vivo. J.Biomaterials. 101, 272-284, 2016.

Rejeski D. Nanotechnology and consumer products. United States Consumer Product Safety Commision. 2009.

Cristóbal LF et al. Antibacterial effect of silver nanoparticles against Streptococcus mutans. Mater Lett. 2009; 63:2603-6.

Cho KH, Park JE, Osaka T, Park SG. The srudy of antimicrobial activity and preservative effects of nanosilver. Electrochim Acta. 2005; 51:956-60.

Deligeorgi V, Mjor IA, Wilson NH,. An overview of reasons for the placement and replacement of restorations. Prim Dent Care. 2001; 8:511.

Jokstad A, Bayne S, Blunck U, Tyas M, Wilson N.. Quality of dental restorations. FDI Commision Projects 295. Int Dent J. 2001;51: 117158.

NIDCR (National Institute of Dental and Craniofacial Research) announcement

#13-DE-102, Dental Resin Composites and Caries, Bethesda, MD, USA, March 5, 2009.

Melo M, Cheng L, Weir MD, Hsia RC, Rodrigues LKA, Xu HHK. Novel dental adhesive containing antibacterial agents and calcium phosphate nanoparticles. Journal of Biomedical Materials Research. Vol. 101B Ed. 4. 2013.

LI Y et al. Bonding durability, antibacterial activity and biofilm pH of novel adhesive containing antibacterial monomer and nanoparticles of amorphous calcium phosphate. Journal of Dentistry. Vol. 81, 91-101. 2019.

Espinosa-Cristóbal LF, Martínez-Castañón GA, Martinez-Martinez RE, Loyola-Rodríguez JP, Patiño-Marin N, Reyes-Macías JF, et al. Antibacterial effect of silver nanoparticles against Streptococcus mutans. Mater Lett 2009;63:26036.

Freire, Priscila L L; Stamford, Thayza C M; Albuquerque, Allan J R; Sampaio, Fabio C; Cavalcante, Horacinna M M; Macedo, Rui O, et al. Action of silver nanoparticles towards biological systems: cytotoxicity evaluation using hen's egg test and inhibition of Streptococcus mutans biofilm formation. Int J Antimicrob Agents; 45(2): 183-7, 2015 Feb.

F. Martínez-Gutierrez, E.P. Thi, J.M. Silverman, C.C. de Oliveira, S.L. Svensson, A. Vanden Hoek, E.M. Sánchez, N.E. Reiner, E.C. Gaynor, E.L. Pryzdial, E.M. Conway, E. Orrantia, F. Ruiz, Y. Av-Gay, H. Bach, Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles, Nanomed. Nanotechnol. Biol. Med. 8 (2012) 328336.

Pérez-Díaz, M. A., Boegli, L., James, G., Velasquillo, C., Sánchez-Sánchez, R., Martínez-Martínez, R.-E., et al. (2015). Silver nanoparticles with antimicrobial activities against Streptococcus mutans and their cytotoxic effect. Materials Science and Engineering: C, 55.


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